Interventional Effects of Traditional Chinese Medicine Compound Formulas on the Expression of Inflammatory Factors in Diabetic Nephropathy

Abstract

DN is still one of the major microcirculatory complications of diabetes mellitus and the leading cause of end stage renal disease worldwide. The advancement of DN is hard to foresee, all we know at present is it’s starting off with long duration minor inflammation. It takes a long time for your blood sugar to be too high, it makes a lot of things happen in your body, just like how it makes you blood move around and how it mixes up with food that gives you energy. And then your body starts making way too many of these special helpers and trouble makers, these help you fight infections, but sometimes your body decides to make too many. The inflammatory mediators are all TNF-α, IL-6, MCP-1, etc., which will lead to glomerular endothelial dysfunction, promoting podocyte damage, mesangial cell hyperplasia, promoting tubulointerstitial fibrosis directly, which are the pathologic characteristics of DN. The conventional treatment mainly focuses on lowering the sugar and blood pressure, which do not stop the progression of the disease, and exploring other complementary and alternative treatments is now inevitable. Traditional Chinese Medicine (TCM) tends to take an overall approach when dealing with things and it’s pretty old at tackling health concerns related to diabetes, and that’s great! Multi-compont Multi-target TCM Fufang. Due to more and more studies on the TCM Fufang to look into the nephro-protective effects. This paper will do review for different kind of TCM compound formula intervention to the key inflammatory factors expression in DN. We’ll see how these formulas change the inflammation, we may show that they can lower TNF-α, IL-6, MCP-1, and other really key stuff, to help kidneys feel good. So the cool thing we figured out is the TCM compound formulas are another sweet treat for DN as this focuses on that big inflammatory piece of the sickness.